Pathology Bibliography

Selected Publications of Michael Lagios, MD
(see Dr. Lagios' expanded CV for complete publications list)

Selected Publications: 2000–Present

Selected Publications: 1990–1999

Selected Publications: 1970–1989

Lagios MD. 2000. Pathology procedures for evaluation of the specimen with potential or documented ductal carcinoma in situ. Seminars in Breast Disease, 3: 42-49.


Consensus Committee. Image-Detected Breast Cancer: State of the Art Diagnosis and Treatment. 2001. J Am College Surg, 193: 297-302.


Lagios MD & Parker SH. 2002. Microcalcification in a core or needle localized biopsy. Am J Surg Pathol, 26: 1238-1239.


Lagios MD. Pathologic practice standards for breast carcinoma: tumor size, reliable data or miscues? J Am Coll Surg, 196: 91-92.


Lagios MD. 2003. Clinical significance of immunohistochemically detectable epithelial cells in sentinel lymph node and bone marrow in breast cancer. J Surg Oncol, 83: 1-4.


Schwartz GF, Lagios MD, Silverstein MJ. 2004. Trends in the treatment of ductal carcinoma in situ of the breast. J Natl Cancer Inst, 96: 1258-1259.


Silverstein MJ, Lagios MD, Recht A, et al. 2005. Image-Detected Breast Cancer: State of the Art Diagnosis and Treatment. J Am Col Surg. 201: 586-597.


Lagios MD. 2006. Problems in the assessment of tumor size: an elusive grail in current practice. Seminars in Breast Disease, 8: 24-30.


Lagios MD, Page DL, Silverstein MJ. 2006. Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol, 24: 3809-3811.


Silverstein MJ and Lagios MD. 2007. Should all patients undergoing breast conserving therapy for DCIS receive radiation therapy? J Surg Oncol, 95: 605-609.


Lagios MD and Silverstein MJ. 2008. Ductal carcinoma in situ: through a glass, darkly. Ann Surg Oncol, 15: 16-17.


Guerra LE, Smith RM, Kaminski A, Lagios MD, Silverstein MJ. 2008. Invasive local recurrence increased after radiation therapy for ductal carcinoma in situ. Am J Surg, 196: 552-555.


Lagios MD. 2009. Theraputic decisions for ductal carcinoma in situ: a Gordian Knot. The Breast Journal, 15: 117-119.


Lagios MD. 2009. Independent consultative review for breast disease: Implications for quality, cost and outcome. Seminars in Breast Disease, 11: 136-139.


Silverstein MJ, Recht A, Lagios MD et al. 2009. Consensus Conference III. Image-detected breast cancer: state-of-the-art diagnosis and treatment. J Am Coll Surg, 209-504-520.


Lagios MD and Silverstein MJ. 2010. Ductal carcinoma in situ: Dilmema or denouement. JCO, 28:


Silverstein MJ and Lagios MD. 2010. Choosing treatment for patients with ductal carcinoma in situ (DCIS): Fine tuning the University of Southern California/Van Nuys Prognostic Index (USC/VNPI). J Nat Can Instit Mono, 41: 193-196.


Wehner P, Lagios MD and Silverstein MJ. 2013. DCIS treated with excision alone using the National Comprehensive Cancer Network (NCCN) Guidelines. Ann Surg Oncol, 20: 3175-3179.


Lagios MD and Silverstein MJ. 2013. Letter to the Editor: A Woman with carcinoma in situ of the breast. N Engl J Med, 368: 2439-2440.


Silverstein MJ and Lagios MD. 2013. Postmastectomy irradiation for DCIS with narrow margins: not for the Festrunk Brothers. Ann Surg Oncol, 28: 1245-1246.


Lagios MD and Silverstein MJ. 2014. Risk of recurrence of ductal carcinoma in situ by Oncotype DX technology: some concerns. Letter, Cancer, 12: 1084-1085.


Silverstein MJ and Lagios MD. 2015. Treatment selection for patients with ductal carcinoma in situ (DCIS) of the breast using the University of Southern California/Van Nuys (USC/VNPI) Prognostic Index. The Breast Journal. In press.


Lagios MD and Silverstein MJ. 2015. Duct carcinoma in situ: recent history and areas of controversy. The Breast Journal, In Press.

Lagios MD and Bennington JL. 1991. Protocol for the Pathologic Examination and Tissue Processing of the Mammographically Directed Breast Biopsy. In: Pathology: State of the Art Reviews. JL Bennington and MD Lagios, Editors. Hanley & Belfus. Philadelphia.


Van Dongen JA, Holland R. Peterse JL, Fentiman IS, Lagios MD, Millis RR and Recht A. 1992. Ductal Carcinoma in situ of the Breast; Second EORTC Consensus Meeting. Eur J Cancer, 28: 626-629.


Lagios MD. 1992. Pathologic Features Related to Local Recurrence Following Lumpectomy and Irradiation. In: Seminars in Surgical Oncology. Wiley-Liss, 8: 122-128.


Lagios MD, and Page DL. 1993. Letter to the Editor: “Radiation Therapy for In Situ or Localized Breast Cancer”. N Eng J Med., 329: 1577-1578.


Page DL and Lagios MD. 1995. Pathologic analysis of the National Surgical Adjuvant Breast Project (NSABP) B-17 Trial: Unanswered questions remaining unanswered considering current concepts of ductal carcinoma in situ. Cancer, 75: 1219-1222.


Lagios MD. 1995. Ductal carcinoma in situ: Controversies in diagnosis, biology and treatment. The Breast Journal, 1: 68-78


Lagios MD. 1996. Classification of duct carcinoma in situ (DCIS) with a characterization of high grade lesions: Defining cohorts for chemoprevention trials. J. Cell Biochem, 255: 108-111.


Lagios MD. 1997. Pathologic procedures for mammographically detected ductal carcinoma in situ. In: Duct Carcinoma In Situ Of The Breast, ed: M Silverstein. Williams & Wilkins, Phaladelphia, p 189-194.


Lagios MD. 1997. Grading of ductal carcinoma in situ. In: Duct Carcinoma In Situ Of The Breast, ed: M Silverstein. Williams & Wilkins, Philadelphia. P 227-232.


Lagios MD. 1997. Lobular carcinoma in situ: An additional perspective. In: Duct Carcinoma In Situ Of The Breast, ed: M Silverstein. Williams & Wilkins, Philadelphia. p 611-616.


Scott MA. Lagios MD, Axelsson K, et al. 1997. Ductal carcinoma in situ of the breast: Reproducibility of histological subtype analysis. Human Path, 28: 967-973.


Schwartz GF, Lagios MD and Consensus Committee. Consensus Conference On The Classification of Ductal Carcinoma In Situ. April, 1997. Cancer, 80: 1789-1802.


Lagios MD. 1998. Prognostic features of breast carcinoma from stereotactic biopsy material. Seminars in Breast Disease, 1: 101-111.


Consensus Committee. Schwartz G, Solin L, Olivotto, et al. Consensus Conference on the Treatment of In Situ Ductal Carcinoma of the Breast. 1999. Cancer 88: 946-954.


Silverstein MJ, Lagios MD, Groshien S, Waisman JR et al. 1999. The influence of margin width on local control of ductal carcinoma in situ of the breast. New England J. Med. 30: 1455-1561.


Sneige N, Lagios MD, Schwarting R, Colburn W, et al. 1999. Interobserver reproducibility of the Lagios Nuclear Grading System for ductal carcinoma in situ. Human Pathol, 30 (3): 257-262.

Lagios MD. 1974. Hormonally enhanced proliferation of human breast cancer in organ culture. An in vitro system for assessment of specific hormonal response. Oncology, 29: 22-23.


Lagios MD. 1977. Multicentricity of breast carcinoma demonstrated by routine correlated serial subgross and radiographic examination. Cancer, 40: 1726-1734.


Lagios MD. 1977. Therapeutic consideration for non-invasive (in situ) breast carcinoma. What’s new in cancer care. Published by the West Coast Cancer Foundation, October, 1977.


Lagios, MD, Gates EA, Westdahl PR, Richards V and Alpert BS. 1979. A guide to the frequency of nipple involvement in breast cancer based on a study of 149 consecutive mastectomies studied in a serial subgross and correlated radiographic technique. Am J Surg, 138: 135-142.


Lagios MD, Rose MR and Margolin FR. 1980. Tubular carcinoma of the breast. Association with multicentricity, bilaterality and family history of breast carcinoma. Am J Clin Pathol, 73: 25-30.


Lagios MD, Westdahl PR and Rose MR. 1981. The concept and implications of multicentricity in breast carcinoma. Pathology Annual, 16: 87-102.


Lagios MD, Westdahl PR, Margolin FR and Rose MR. 1982. Duct carcinoma in situ. Relationship of extent of noninvasive disease to the frequency of occult invasion, multicentricity, lymph node metastases, and short-term failures. Cancer, 50: 1309-1314.


Lagios MD, Richards VE, Rose MR and Yee E. 1983. Segmental mastectomy without radiotherapy. Short term followup. Cancer, 52: 2173-2179.


Lagios MD. 1983. Human Breast Precancer: Current Status. In: Cancer Surveys. L.M. Franks, Editor, Oxford University Press. London.


Lagios MD, Westdahl PR, Rose MR and Stasko-Concannon S. 1984. Paget’s disease of the nipple: Alternative management in cases without or with minimal extent of underlying breast carcinoma. Cancer, 54: 167-173.


Margolin FR and Lagios MD. 1986. Mammographic detection of early breast cancer - ten year’s experience in a community hospital. West J Med, 144: 46-48.


Lagios MD, Margolin FR, Westdahl PR, Rose MR. 1989. Mammographically detected duct carcinoma in situ: Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence. Cancer, 63: 618-624.